reactivation of cytomegalovirus in a patient with stevens-johnson syndrome-toxic epidermal necrolysis

نویسندگان

mohamed rida tagajdid laboratory of virology, mohamed v souissi university, mohamed v military teaching hospital, rabat, bp, morocco

taoufik doblali laboratory of virology, mohamed v souissi university, mohamed v military teaching hospital, rabat, bp, morocco

hicham elannaz laboratory of virology, mohamed v souissi university, mohamed v military teaching hospital, rabat, bp, morocco

salaheddine hammi department of internal medicine, mohamed v military teaching hospital, rabat, bp, morocco

چکیده

stevens-johnson syndrome (sjs) and toxic epidermal necrolysis (ten) are severe adverse cutaneous reactions to drugs. we describe the case of a 19 year old patient with sjs/ten overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. a cytomegalovirus infection was diagnosed by real time polymerase chain reaction (rt-pcr) detection on bronchoalveolar lavage. based on observations on biological data, temporal relationship, and clinical features, it could be inferred that the reactivation of cytomegalovirus with viral replication can predispose a person to ten-sjs. we discuss here, in the light of the current literature, the probable association between drug-induced sjs-ten and fulminant reactivation of cytomegalovirus.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveo...

متن کامل

Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveo...

متن کامل

[Stevens-Johnson syndrome/toxic epidermal necrolysis].

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe skin reaction most often triggered by particular medications. Although Stevens-Johnson syndrome and toxic epidermal necrolysis were once thought to be separate conditions, they are now considered part of a continuum. Stevens-Johnson syndrome represents the less severe end of the disease spectrum, and toxic epidermal necro...

متن کامل

Toxic epidermal necrolysis and Stevens-Johnson syndrome

Three cases are described in which Stevens-Johnson syndrome progressed in the course of a few days to toxic epidermal necrolysis. Trimethoprim-sulfamethoxazole, allopurinol in combination with hydrochlorothiazide, phenytoin and possibly ampicillin were implicated in the causation of the disease.

متن کامل

Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome

The term toxic epidermal necrolysis (TEN) was introduced in 1956 by Lyell to describe four patients with a syndrome featured by extensive epidermal detachment with mucous membrane involvement, leaving the skin surface looking scalded. Necrolysis denotes necrosis and full thickness detachment of the epidermis. Toxic means severe constitutional symptoms and complications. Stevens-Johnson syndrome...

متن کامل

New insights in Stevens Johnson syndrome/ toxic epidermal necrolysis syndrome

Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening cutaneous severe adverse reactions (SCAR) most frequently induced by a drug hypersensitivity. The clinical manifestations seem to be related either to a particular group of drugs, such as antibacterial sulfonamides, anticonvulsant agents, allopurinol, non-steroidal anti-inflammatory drugs (NSAIDs), am...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of medical sciences

جلد ۳۸، شماره ۲، صفحات ۱۹۵-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023